BDBM50368973 CHEMBL4161483::US11124537, TABLE 3.11.1

SMILES [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(N(C)C)c(C)c1

InChI Key InChIKey=PWLQZIZXAQFNOL-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50368973   

TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368973(CHEMBL4161483 | US11124537, TABLE 3.11.1)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368973(CHEMBL4161483 | US11124537, TABLE 3.11.1)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at AR (unknown origin) expressed in human LNCaP cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368973(CHEMBL4161483 | US11124537, TABLE 3.11.1)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at human GR expressed in CHO-K1 cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368973(CHEMBL4161483 | US11124537, TABLE 3.11.1)
Affinity DataIC50: 100nMAssay Description:Cell Line: CHO-K1-GR-MMTV-Luc reporter cellsCulture Media: DMEM (with phenol red)+10% FBSAssay Media: DMEM (without phenol red)+10% CSSCulture CHO-K1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent