BDBM50364033 CHEMBL1224151

SMILES COc1cc(\C=C2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1

InChI Key InChIKey=PUOAETJYKQITMO-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50364033   

LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 85nMAssay Description:Modulation of gamma-secretase in HEK293 cells expressing Swedish mutant APP assessed as inhibition of intracellular amyloid beta 42 production after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 560nMAssay Description:Modulation of gamma-secretase in HEK293 cells expressing Swedish mutant APP assessed as inhibition of intracellular amyloid beta 40 production after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human ERG by cell based voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 80nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as reduction in amyloid beta 42 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 83nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 64nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 64nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataEC50:  83nMAssay Description:Modulation of human gamma-secretase assessed as inhibition of amyloid beta (1 to 42 residues) production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364033(CHEMBL1224151)
Affinity DataIC50: 64nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed