BDBM50363804 CHEMBL1946917

SMILES Oc1ccc2[nH]c3c(c2c1)c1ccc(O)cc1oc3=O

InChI Key InChIKey=AJTBUWMKUOLMNM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50363804   

LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 300nMAssay Description:Inhibition of GST-tagged rat recombinant DYRK1A expressed in Escherichia coli using myelin basic protein as substrate and [gamma-33P]ATP after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-33P]ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 67nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 720nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 310nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 39nMAssay Description:Inhibition of DNA topoisomerase 1 (unknown origin) at 50 uM measured by agar gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed