BDBM50363773 CHEMBL1945137::US9365508, 331a (4-isopropyl)

SMILES CC(C)c1ccc(cc1)C(=O)NC(=S)Nc1ccc(NC(=O)CCCCN(C)C)cc1

InChI Key InChIKey=UTQHGPPEEJLEOE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50363773   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50: 6.48E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50: 3.25E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50: 4.27E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50: 5.71E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed