BDBM50362177 CHEMBL1938689

SMILES Cc1cnc2-c3oc(cc3Cc3cc(ccc3-n12)N1CCNCC1)-c1ccc(Cl)cc1

InChI Key InChIKey=CDAOXEMWBDQTEE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50362177   

TargetMAP kinase-activated protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362177(CHEMBL1938689)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of MK2 using TAMRA-labeled peptide as substrate pre-incubated for 30 mins prior substrate addition measured after 30 mins incubation in da...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362177(CHEMBL1938689)
Affinity DataEC50:  2.50E+3nMAssay Description:Inhibition of MK2-mediated HSP27 phosphorylation at Ser78 in LPS-stimulated human THP-1 cells pre-incubated for 60 mins before LPS treatment measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed