BDBM50361645 CHEMBL1234429::US9873693, Compound 144

SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc1F

InChI Key InChIKey=GCWCGSPBENFEPE-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50361645   

LigandPNGBDBM50361645(CHEMBL1234429 | US9873693, Compound 144)
Affinity DataEC50:  1nMAssay Description:Inhibition of PDK1-mediated AKT1 phosphorylation at T308 in human H460 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1 [51-360](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM50361645(CHEMBL1234429 | US9873693, Compound 144)
Affinity DataIC50: 500nMAssay Description:A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50361645(CHEMBL1234429 | US9873693, Compound 144)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant ASK1 using MBP as substrate preincubated for 1 hr followed by reagent addition incubated for 40 mins by ATP-Glo kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50361645(CHEMBL1234429 | US9873693, Compound 144)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed