BDBM50361576 CHEMBL1939497::CHEMBL1939498

SMILES CN1CCCC[C@H]1[C@@H](NC(=O)c1cccc(c1I)C(F)(F)F)c1ccccc1

InChI Key InChIKey=NVMKECIXYGQWGJ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50361576   

TargetSodium- and chloride-dependent glycine transporter 1(Rat)
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50361576(CHEMBL1939498 | CHEMBL1939497)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to GlyT1 in rat cortical brain homogenate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50361576(CHEMBL1939498 | CHEMBL1939497)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed