BDBM50361575 CHEMBL1939495

SMILES CN1CCCC[C@H]1[C@@H](NC(=O)c1cccc(c1Cl)C(F)(F)F)c1ccccc1

InChI Key InChIKey=XPXKFXNVIAOBEI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361575   

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50361575(CHEMBL1939495)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50361575(CHEMBL1939495)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50361575(CHEMBL1939495)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed