BDBM50361089 CHEMBL1933576

SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc(cn2C)C(N)=O)c1

InChI Key InChIKey=HGBZKLOZYQAERY-UHFFFAOYSA-N

Data  38 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50361089   

TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NEK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
Target40S ribosomal protein S27(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MST4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAP-KAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKAalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK4/cyclin D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 15nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDC7More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50361089(CHEMBL1933576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed