BDBM50359393 CHEMBL1926712::US8999994, 2

SMILES CN(CC#C)Cc1cc2cc(OCCCN3CCC(Cc4ccccc4)CC3)ccc2n1C

InChI Key InChIKey=ZOKJNFBIMVLFEW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50359393   

TargetAcetylcholinesterase(Electric eel)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 1.81E+4nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCarboxylic ester hydrolase(Horse)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 2.20E+3nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 6.54E+4nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 1.13E+7nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of rat liver mitochondrial MAO-B using [14C]-phenylethylamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 65nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of equine serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359393(CHEMBL1926712 | US8999994, 2)
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed