BDBM50358743 CHEMBL1922270

SMILES C[C@@H]1[C@H]2CN(CCCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F

InChI Key InChIKey=VGWOOKCYUNUQRH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50358743   

LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human MCHR1 expressed in Jurkat cells co-expressing apoaequorin assessed as inhibition of MCH-induced calcium mobilization by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-MCH from MCHR1 after 2 hrs by beta scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat MCHR1 expressed in HEK293 cells by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Crab-eating macaque)
Amgen

Curated by ChEMBL
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at cynomolgus monkey MCHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-MCH from MCHR1 after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed