BDBM50355691 CHEMBL1910998

SMILES Oc1cccc2n(c(nc12)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1

InChI Key InChIKey=WFRUFWRKGZIARP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50355691   

LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human His-tagged PI3K p110alpha after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human His-tagged PI3K p110beta after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PIK3CA-mediated cell signaling in PTEN-deficient human U87MG cells assessed as inhibition of insulin-induced pAkt/PKB phosphorylation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of mouse recombinant PI3K p110alpha expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human His-tagged PI3K p110delta after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 6nMAssay Description:Inhibition of human His-tagged PI3K p110gamma after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50355691(CHEMBL1910998)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PIK3CA-mediated cell signaling in PTEN-deficient human U87MG cells assessed as inhibition of insulin-induced pAkt/PKB phosphorylation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed