BDBM50355491 CHEMBL1835870

SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1

InChI Key InChIKey=OYUDNKFIGXAIRZ-UHFFFAOYSA-N

Data  14 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50355491   

TargetMast/stem cell growth factor receptor Kit(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-KIT-mediated ERK 1/2 phosphorylation in human TF1 cells at 4 to 12 nM after 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataIC50: 4nMAssay Description:Inhibition of SCF-induced phosphorylation of c-KIT in human TF1 cells after 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human recombinant FLT3 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  2nMAssay Description:Displacement of [33P]ATP from human recombinant FLT3 domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  40nMAssay Description:Inhibition of AXLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  85nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  130nMAssay Description:Inhibition of cMETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  200nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  200nMAssay Description:Inhibition of PDGFR-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  220nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  280nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  400nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  400nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  400nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  400nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355491(CHEMBL1835870)
Affinity DataKi:  770nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed