BDBM50355468 CHEMBL1835743

SMILES Nc1nc(Nc2cc(ccc2F)N2CCOCC2)nn1-c1ccccn1

InChI Key InChIKey=GXJJTQDCWLONOL-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50355468   

TargetMast/stem cell growth factor receptor Kit(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataIC50: 760nMAssay Description:Inhibition of human recombinant c-Kit by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant FLT3 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataKi:  12nMAssay Description:Displacement of [33P]ATP from human recombinant FLT3 domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataKi:  37nMAssay Description:Displacement of [33P]ATP from human recombinant c-KIT domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataKi:  440nMAssay Description:Inhibition of IRAK4 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataKi:  590nMAssay Description:Inhibition of JAK2 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of Aurora A by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed