BDBM50352205 CHEMBL1825096

SMILES CS(=O)(=O)Nc1ccc(cn1)Nc2ncc3cnn(c3n2)C4CCCCCC4

InChI Key InChIKey=PARUULGUCQEWNM-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50352205   

TargetCytochrome P450 3A4(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 using a fluorescent probe 7-benzyloxy-4(trifluoromethyl)-coumarinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 using a fluorescent probe 7-benzyloxyquinolineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 using a fluorescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 using a fluorescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4methylcoumarinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 17nMAssay Description:Inhibition of Aurora kinase A assessed as phosphorylation of Lats2 substrate at 0.017 to 30 nM by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50352205(CHEMBL1825096)
Affinity DataIC50: 7nMAssay Description:Inhibition of CDK1/Cyclin B assessed as phosphorylation of Z-lyte Peptide at 0.017 to 30 nM by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed