BDBM50350908 CHEMBL520308

SMILES CN(CCO)S(=O)(=O)c1ccc(cc1)-c1ccnc2[nH]c(C)cc12

InChI Key InChIKey=FKJNWJPAAVSRNX-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50350908   

TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 15nMAssay Description:Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 794nMAssay Description:Inhibition of IKK2 in human A549 cells assessed as inhibition of TNFalpha-induced NFKB activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 39.8nMAssay Description:Inhibition of IKK2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 40nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAurora kinase A-interacting protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of GSK3-beta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed