BDBM50350169 CHEMBL1814633::US11096924, DASH-inhibitors 4160 (1G 244)::US11559537, Compound 4160(1G-244)

SMILES c1ccc2c(c1)CN(C2)C(=O)[C@H](CC(=O)N3CCN(CC3)C(c4ccc(cc4)F)c5ccc(cc5)F)N

InChI Key InChIKey=ZKIQFLSGMMYCGS-UHFFFAOYSA-N

Data  19 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50350169   

TargetDipeptidyl peptidase 4(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.00E+6nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 8/9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.40E+3nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProlyl endopeptidase(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.00E+4nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetProlyl endopeptidase FAP(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 2.20E+3nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.00E+3nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 490nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 400nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8/9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.40E+6nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHomeobox protein PKNOX1(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.00E+7nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetProlyl endopeptidase FAP(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 2.20E+6nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 8(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 4.90E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 4.00E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 2(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 53nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 14nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 2(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed