BDBM50349299 CHEMBL1808458

SMILES Cc1cc(cc(Cl)c1NC(=O)N1CCn2c(C1)c(O)n([C@H]1C[C@@H]1c1ccccc1)c2=O)C#N

InChI Key InChIKey=WUFPRCXHCONSJQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50349299   

TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349299(CHEMBL1808458)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349299(CHEMBL1808458)
Affinity DataIC50: 84nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed