BDBM50346049 2,8-dimethyl-5-(2-pyrazine-2-ylethyl)-gamma-carboline::CHEMBL1783970

SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cnccn1

InChI Key InChIKey=DUUHEGAGOHEODE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50346049   

TargetHistamine H1 receptor(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50346049(2,8-dimethyl-5-(2-pyrazine-2-ylethyl)-gamma-carbol...)
Affinity DataIC50: 7.94E+3nMAssay Description:Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50346049(2,8-dimethyl-5-(2-pyrazine-2-ylethyl)-gamma-carbol...)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50346049(2,8-dimethyl-5-(2-pyrazine-2-ylethyl)-gamma-carbol...)
Affinity DataIC50: 2.06E+3nMAssay Description:Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed