BDBM50345596 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(pyridin-3-ylethynyl)benzamide::CHEMBL1784625

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cccnc3)cc2C(F)(F)F)CC1

InChI Key InChIKey=QAOMWMNQOYMGAR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345596   

TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345596(4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(...)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50345596(4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of wild type KIT (unknown origin) using biotinylated poly-Glu-Tyr as substrate preincubated for 30 mins followed by substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed