BDBM50344073 CHEMBL1777866::rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)hex-4-ynoic acid

SMILES CC#CC(CC(O)=O)c1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1

InChI Key InChIKey=KJKPJGXGFQYFKV-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50344073   

TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344073(rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl...)
Affinity DataEC50:  108nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344073(rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl...)
Affinity DataEC50:  409nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344073(rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344073(rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed