BDBM50342279 (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-benzofuran-3-yl)methanone::CHEMBL1767079::US9725430, Compound 1g::US9962362, Compound 1g

SMILES CCc1c(c2ccc(cc2o1)O)C(=O)c3cc(c(c(c3)Br)O)Br

InChI Key InChIKey=FEXBXMFVRKZOOZ-UHFFFAOYSA-N

Data  6 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50342279   

TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 138nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human URAT1 expressed in human MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 2.72E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 2.72E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 200nMAssay Description:Inhibition of URAT1 (unknown origin) transfected in dog MDCK cells assessed as inhibition of [14C]uric acid uptake by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of acid mediated TTR V30M mutant aggregation (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by acetic bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataKd:  700nMAssay Description:Binding affinity to thyroxin binding site of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching of intrinsic trypto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)