BDBM50341069 2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile::CHEMBL1615182::[(4-{2-[(3-hydroxyphenyl)amino]-1H-benzimidazol-1-yl}-1,3,5-triazin-2-yl)amino]acetonitrile

SMILES Oc1cccc(Nc2nc3ccccc3n2-c2ncnc(NCC#N)n2)c1

InChI Key InChIKey=FEBJYEFFVIDUNF-UHFFFAOYSA-N

Data  4 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50341069   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 700nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 97nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TGFR2 at 1 uM relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of DCAMKL3 at 1 uM relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CK1delta at 1 uM relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of KDR at 1 uM relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of c-Raf at 1 uM relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 240nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 380nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 320nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  52nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  120nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  190nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  350nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed