BDBM50341040 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzimidazol-2-amine::1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzo[d]imidazol-2-amine::CHEMBL1615183

SMILES Cc1nc(N)nc(n1)-n1c(Nc2ccn[nH]2)nc2ccccc12

InChI Key InChIKey=DMMFPXAFVNDPCA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50341040   

LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 800nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 870nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 510nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 320nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 390nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 55nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 27nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 23nMAssay Description:Inhibition of mTOR by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 875nMAssay Description:Inhibition of PI3Kbeta by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50: 798nMAssay Description:Inhibition of PI3Kalpha by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed