BDBM50341036 CHEMBL1760155::N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenyl)acetamide

SMILES CC(=O)Nc1ccc(Nc2nc3ccccc3n2-c2nc(C)nc(N)n2)cc1

InChI Key InChIKey=XOVOMIOHGLZGJN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341036   

LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 23nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 410nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 71nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 340nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 180nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50341036(N-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed