BDBM50341023 CHEMBL1762293::N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyran-4-carbonyl)-1,4-diazepane-1-carboxamide

SMILES CC(C)(C)c1cc(NC(=O)N2CCCN(CC2)C(=O)C2CCOCC2)no1

InChI Key InChIKey=MIBQBFVAZRBAFD-UHFFFAOYSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50341023   

TargetCannabinoid receptor 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341023(N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyr...)
Affinity DataEC50:  67nMAssay Description:Agonist activity at human CB2 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341023(N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyr...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB1 receptor transfected in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341023(N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 using fluorescent probe 7-benzyloxyquinoline and 7-benzyloxy-4-(trifluoromethyl)-coumarin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341023(N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 fluorescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341023(N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 using fluorescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341023(N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyr...)
Affinity DataEC50:  67nMAssay Description:Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed