BDBM50340954 CHEMBL1762110::Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methyl)acetamide

SMILES CC(=O)NC[C@H]1CC[C@@H](CC1)c1nc(-c2cc3ccccc3[nH]2)c2c(N)nccn12

InChI Key InChIKey=MKMYAVUUMSCFQQ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50340954   

TargetInsulin receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 180nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 4.21E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 960nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed