BDBM50339016 3,4-dihydroisoquinolin-1(2H)-one::CHEMBL1688212

SMILES c1ccc2c(c1)CCNC2=O

InChI Key InChIKey=YWPMKTWUFVOFPL-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50339016   

TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PARP-10 (unknown origin) mediated ADP-ribosylation of SRPK2 by fluorescence analysis using 3 uM SRPK2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP1 (unknown origin) by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of PARP-10 L926G mutant (unknown origin) mediated ADP-ribosylation of SRPK2 by fluorescence analysis using 3 uM SRPK2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of PARP-10 L926G mutant (unknown origin) mediated ADP-ribosylation of SRPK2 by fluorescence analysis using 3 uM SRPK2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 1.69E+5nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 7.08E+4nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50339016(3,4-dihydroisoquinolin-1(2H)-one | CHEMBL1688212)
Affinity DataIC50: 7.03E+4nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed