BDBM50337958 CHEMBL1684242::N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide

SMILES Fc1cccc(c1)C#Cc1ccc(cn1)C(=O)NC1CCC1

InChI Key InChIKey=NEMHWVUKNWAKTM-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50337958   

TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinami...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinami...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinami...)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed