BDBM50337285 3-[N-(4-bromophenyl)amino]benzoic acid::CHEMBL1682204::US9271961, 9

SMILES OC(=O)c1cccc(Nc2ccc(Br)cc2)c1

InChI Key InChIKey=QGRMQUFALFJLGQ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50337285   

TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 120nMAssay Description:Inhibition of AKR1C3 by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX2 expressed in baculovirus infected SF-21 cells assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant AKR1B10 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant AKR1B1 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C4(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 9.14E+4nMAssay Description:Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant AKR1C3 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 3.13E+4nMAssay Description:Inhibition of recombinant AKR1C1 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of AKR1C2 by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C4(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 9.14E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 1(Human)
University of Pennsylvania

US Patent
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member B10(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 5.00E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member B1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 5.00E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 3.13E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 1.80E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337285(3-[N-(4-bromophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: 120nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent