BDBM50337135 4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)benzenesulfonamide::Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 6::CHEMBL1673047::US11155556, No. 16

SMILES CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3)S(N)(=O)=O)nc12

InChI Key InChIKey=CRFHZXHUGPCWJA-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50337135   

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 3.40nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 8.40nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 310nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase DCLK1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 187nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 49nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 14.5nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Harvard Medical School

LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 4.80nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 13.3nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent