BDBM50336747 5-[3-Methoxy-4-(2-nitro-4-trifluoromethylphenoxy)benzylidene]-thiazolidine-2,4-dione::CHEMBL1671955

SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1Oc1ccc(cc1[N+]([O-])=O)C(F)(F)F

InChI Key InChIKey=ILKFSEKZOCZUAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50336747   

TargetSteroid hormone receptor ERR1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50336747(5-[3-Methoxy-4-(2-nitro-4-trifluoromethylphenoxy)b...)
Affinity DataIC50: 270nMAssay Description:Antagonist activity at 6his-tagged ERRalpha LBD assessed as inhibition of recruitment of GST-labeled coactivator Scr2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50336747(5-[3-Methoxy-4-(2-nitro-4-trifluoromethylphenoxy)b...)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed