BDBM50336578 3-(biphenyl-4-yloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL1672069

SMILES O=c1nc2c3cccc4c(Oc5ccc(cc5)-c5ccccc5)ccc(c2c1C#N)c34

InChI Key InChIKey=BRYQRJBYNBYHAH-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50336578   

TargetApoptosis regulator Bcl-2(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336578(3-(biphenyl-4-yloxy)-8-oxo-8H-acenaphtho[1,2-b]pyr...)
Affinity DataKi:  278nMAssay Description:Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336578(3-(biphenyl-4-yloxy)-8-oxo-8H-acenaphtho[1,2-b]pyr...)
Affinity DataKi:  1.28E+3nMAssay Description:Displacement of FAM-Bid from human Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50336578(3-(biphenyl-4-yloxy)-8-oxo-8H-acenaphtho[1,2-b]pyr...)
Affinity DataKi:  1.28E+3nMAssay Description:Displacement of FAM-Bid peptide from human Mcl-1 after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed