BDBM50336316 CHEMBL410659::cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine::cis-3-(3-azetidin-1-ylmethylcyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-ylamine

SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@H](CN2CCC2)C1

InChI Key InChIKey=FUGZYLOFWXVFQU-UHFFFAOYSA-N

Data  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50336316   

TargetRho-associated protein kinase 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Rock2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human purified insulin receptor expressed in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant full length IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AuroraAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of KDR at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336316(cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phe...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed