BDBM50335843 (5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione::CHEMBL1650673::CHEMBL1650676

SMILES CCn1c(O)c2Cc3c([nH]c4ccccc34)[C@@H](c3ccc(Cl)cc3Cl)n2c1=O

InChI Key InChIKey=SDUQIRJPZKDQNS-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50335843   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant PDE3B-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant PDE4B-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant PDE3B-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant PDE3B-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant PDE3B-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843(CHEMBL1650676 | CHEMBL1650673 | (5R,11aR)5-(2,4-Di...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human recombinant PDE4B-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed