BDBM50335815 CHEMBL1650658::N-{3-[2-Hydroxy-6-(3-hydroxyphenyl)-1-naphthyl]phenyl}-methanesulfonamide::US8546392, 56::US8546392, 72

SMILES CS(=O)(=O)Nc1cccc(c1)-c1c(O)ccc2cc(ccc12)-c1cccc(O)c1

InChI Key InChIKey=FRZBNIHVXARHST-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50335815   

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 23nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 540nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 680nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2013
Entry Details
Go to US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 71nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | US8546392, 72 | US8546392, 56 | N-...)
Affinity DataIC50: 403nMAssay Description:Displacement of [3H]E2 from human placental 17beta-HSD2 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed