BDBM50335233 3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluoromethyl-phenyl)-pyrrole-2,5-dione::CHEMBL1650953

SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCNCC1

InChI Key InChIKey=KSWPVLJUULLKJR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335233   

TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 737nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 133nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed