BDBM50334268 CHEMBL1642655::CHEMBL2205637::N-(6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide

SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cn2cc(ccc2n1)-n1ccnc1

InChI Key InChIKey=SMJAMOAYGIVKRI-UHFFFAOYSA-N

Data  23 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50334268   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 14nMAssay Description:Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of PRKAA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of recombinant human GST-tagged MER cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 cytoplasmic domain (708 to 993 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged RON cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of recombinant human GST-tagged RET cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant full length human GST-tagged ITK expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 832nMAssay Description:Inhibition of recombinant full length human His-tagged GSK3B expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 155nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ASK1 assessed as phosphorylated fluorescent peptide by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 6(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 510nMAssay Description:Inhibition of ASK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group C member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKKbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50334268(CHEMBL2205637 | CHEMBL1642655 | N-(6-(1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed