BDBM50332283 (R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(pyridin-3-ylethynyl)imidazolidine-2,4-dione::CHEMBL1287851

SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3cccnc3)C(=O)c2c1

InChI Key InChIKey=FYZPCUXRTDXRBF-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50332283   

TargetMatrix metalloproteinase-9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 431nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 2.92E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.620nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed