BDBM50332020 CHEMBL1289468::N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NS(=O)(=O)c2ccccc2)c1

InChI Key InChIKey=CZLHISAYBVESEH-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332020   

TargetMast/stem cell growth factor receptor Kit(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332020(N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataIC50: 126nMAssay Description:Inhibition of c-KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332020(N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332020(N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataKd:  91nMAssay Description:Binding affinity to TRKA by high throughput assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332020(N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to PI3Kalpha by high throughput assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332020(N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed