BDBM50332019 5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-3-amine::CHEMBL1289467

SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(N)c1

InChI Key InChIKey=UOEZVMBYMMMIIY-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332019   

TargetMast/stem cell growth factor receptor Kit(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332019(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataIC50: 11nMAssay Description:Inhibition of c-KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332019(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332019(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataKd:  58nMAssay Description:Binding affinity to TRKA by high throughput assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332019(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataKd:  960nMAssay Description:Binding affinity to PI3Kalpha by high throughput assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Korea Advanced Institute of Science and Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332019(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataIC50: 460nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed