BDBM50330933 CHEMBL1277514::N-(3,5-Dimethylphenyl)-6-(4-chlorophenyl)-pyrazine-2-carboxamide

SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(Cl)cc2)c1

InChI Key InChIKey=QFMYRESYPSSSRX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330933   

TargetSodium channel protein type 10 subunit alpha(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(N-(3,5-Dimethylphenyl)-6-(4-chlorophenyl)-pyrazine...)
Affinity DataIC50: 490nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(N-(3,5-Dimethylphenyl)-6-(4-chlorophenyl)-pyrazine...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(N-(3,5-Dimethylphenyl)-6-(4-chlorophenyl)-pyrazine...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(N-(3,5-Dimethylphenyl)-6-(4-chlorophenyl)-pyrazine...)
Affinity DataIC50: 52nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed