BDBM50330575 (-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)-2,3-dimethylpiperidine-4-carboxylic Acid::CHEMBL1276848

SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c(n1)N1CC[C@H]([C@@H](C)[C@H]1C)C(O)=O

InChI Key InChIKey=YPKLAWUGDWZBMV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50330575   

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330575((-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxypheny...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330575((-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxypheny...)
Affinity DataIC50: 230nMAssay Description:Inhibition of NEK2 by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330575((-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxypheny...)
Affinity DataIC50: 200nMAssay Description:Inhibition of NEK2 assessed as inhibition of substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330575((-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxypheny...)
Affinity DataIC50: 300nMAssay Description:Inhibition of NEK2 assessed as inhibition of substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330575((-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxypheny...)
Affinity DataIC50: 170nMT: 2°CAssay Description:Inhibition of NEK1 after 1 hr at room temperature by caliper methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330575((-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxypheny...)
Affinity DataIC50: 1.94E+4nMT: 2°CAssay Description:Inhibition of PLK1 after 75 mins at room temperature by caliper methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed