BDBM50330550 CHEMBL1277474::N-(4-chlorophenyl)-2,7,7-trimethyl-5-oxo-4-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide

SMILES CC1=C(C(C2C(=O)CC(C)(C)CC2=N1)c1ccccc1)C(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=LVJNXLPLFAZAJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330550   

TargetKinesin-like protein KIF11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330550(N-(4-chlorophenyl)-2,7,7-trimethyl-5-oxo-4-phenyl-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330550(N-(4-chlorophenyl)-2,7,7-trimethyl-5-oxo-4-phenyl-...)
Affinity DataIC50: 4.03E+4nMAssay Description:Inhibition of human purified recombinant aurora-A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330550(N-(4-chlorophenyl)-2,7,7-trimethyl-5-oxo-4-phenyl-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant Eg5 ATPase activity expressed in Escherichia coli after 30 mins by malachite green-based spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed