BDBM50329560 (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(3,3,3-trifluoropropoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1270136

SMILES CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1cccc(OCCC(F)(F)F)c1

InChI Key InChIKey=QLEGEHLCGYEGPB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329560   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329560((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329560((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed