BDBM50329526 (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-pentylphenyl)-1H-imidazol-5(4H)-one::CHEMBL1270027

SMILES CCCCCc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1

InChI Key InChIKey=GPIGHALYCORADP-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329526   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329526((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataEC50:  530nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329526((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed