BDBM50328477 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine::CHEMBL1259203

SMILES CN1CCC(CC1)c1cn(-c2ccc(F)cc2)c2ccc(cc12)-c1cncnc1

InChI Key InChIKey=WAWSGWZTHJAPIA-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50328477   

TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]prozosin from bovine cloned Alpha-1A receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]prazosine from bovine alpha1A adrenoceptor expressed in BHK cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]prozosin from hamster cloned alpha-1b receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]prozosin from rat cloned alpha1d receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]CT from human 5-HT1B receptor expressed in human HeLa cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50328477(1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed