BDBM50328257 5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepin-7-amine::CHEMBL1257911

SMILES Nc1ccc2Nc3[nH]ncc3N=C(c3ccccc3Cl)c2c1

InChI Key InChIKey=LRLOMPHFTKHYKN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50328257   

TargetEpidermal growth factor receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328257(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50: 989nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50328257(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50: 88nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328257(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50: 150nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328257(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328257(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50: 34nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed