BDBM50327939 7-methoxytacrine::CHEMBL1256415

SMILES COc1ccc2nc3CCCCc3c(N)c2c1

InChI Key InChIKey=APQPVVOYBLOJDY-UHFFFAOYSA-N

Data  4 KI  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50327939   

TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured at 1 min ti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 8.86E+3nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rat)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 4.93E+4nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rat)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of recombinant human BuChE using butyrylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine as substrate by DTNB-reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 3.71E+3nMAssay Description:Antagonist activity at human M1 mAChR expressed in CHO cells assessed as inhibition of oxotremorine M-stimulated calcium influx preincubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of human plasmatic BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human recombinant AChE after 5 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine substrate preincubated for 5 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human plasmatic BChE using butylthiocholne substrate preincubated for 5 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human plasmatic BChE after 5 mins using spectrophotometer by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human recombinant AChE after 5 mins using spectrophotometer by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant AChE after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human plasmatic BChE after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of human plasmatic BChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human BuChE pre-incubated for 5 mins before butylthiocholine substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant AChE pre-incubated for 5 mins before acetylthiocholine substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alma Mater Studiorum - University of Bologna

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human plasmatic BChE after 5 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataKi:  2.09E+3nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataKi:  2.09E+3nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataKi:  6.34E+3nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex using acetylthiocholine substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataKi:  6.34E+3nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed