BDBM50319985 CHEMBL1083622::N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-yloxy)piperidine-1-carboxamide

SMILES Fc1ccc(cc1)C(CCNC(=O)N1CCC(CC1)Oc1cnccn1)c1ccc(F)cc1

InChI Key InChIKey=MPNWZPXDQGSZCC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319985   

TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-ylo...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-ylo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-ylo...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed